BDBM50325185 6-(((3S,4S)-4-((3'-Chlorobiphenyl-4-yl)methoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine::CHEMBL1222677

SMILES: Cc1cc(N)nc(C[C@@H]2CNC[C@@H]2OCc2ccc(cc2)-c2cccc(F)c2)c1

InChI Key: InChIKey=YFLMTTKOWRHZTR-OFNKIYASSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50325185   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nitric-oxide synthase, brain (Rattus norvegicus (rat))	BDBM50325185 (6-(((3S,4S)-4-((3'-Chlorobiphenyl-4-yl)methoxy)pyr...) Show SMILES Cc1cc(N)nc(C[C@@H]2CNC[C@@H]2OCc2ccc(cc2)-c2cccc(F)c2)c1 |r| Show InChI InChI=1S/C24H26FN3O/c1-16-9-22(28-24(26)10-16)12-20-13-27-14-23(20)29-15-17-5-7-18(8-6-17)19-3-2-4-21(25)11-19/h2-11,20,23,27H,12-15H2,1H3,(H2,26,28)/t20-,23+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	750	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northwestern University Curated by ChEMBL					Assay Description Inhibition of rat recombinant nNOS expressed in Escherichia coli by hemoglobin capture assay				Bioorg Med Chem 18: 6526-37 (2010) Article DOI: 10.1016/j.bmc.2010.06.074 BindingDB Entry DOI: 10.7270/Q26110HX
					More data for this Ligand-Target Pair
Nitric Oxide Synthase, endothelial (Bos taurus (bovine))	BDBM50325185 (6-(((3S,4S)-4-((3'-Chlorobiphenyl-4-yl)methoxy)pyr...) Show SMILES Cc1cc(N)nc(C[C@@H]2CNC[C@@H]2OCc2ccc(cc2)-c2cccc(F)c2)c1 |r| Show InChI InChI=1S/C24H26FN3O/c1-16-9-22(28-24(26)10-16)12-20-13-27-14-23(20)29-15-17-5-7-18(8-6-17)19-3-2-4-21(25)11-19/h2-11,20,23,27H,12-15H2,1H3,(H2,26,28)/t20-,23+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.33E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northwestern University Curated by ChEMBL					Assay Description Inhibition of bovine recombinant eNOS expressed in Escherichia coli by hemoglobin capture assay				Bioorg Med Chem 18: 6526-37 (2010) Article DOI: 10.1016/j.bmc.2010.06.074 BindingDB Entry DOI: 10.7270/Q26110HX
					More data for this Ligand-Target Pair
Nitric Oxide Synthase, inducible (Mus musculus (mouse))	BDBM50325185 (6-(((3S,4S)-4-((3'-Chlorobiphenyl-4-yl)methoxy)pyr...) Show SMILES Cc1cc(N)nc(C[C@@H]2CNC[C@@H]2OCc2ccc(cc2)-c2cccc(F)c2)c1 |r| Show InChI InChI=1S/C24H26FN3O/c1-16-9-22(28-24(26)10-16)12-20-13-27-14-23(20)29-15-17-5-7-18(8-6-17)19-3-2-4-21(25)11-19/h2-11,20,23,27H,12-15H2,1H3,(H2,26,28)/t20-,23+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.95E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northwestern University Curated by ChEMBL					Assay Description Inhibition of mouse recombinant iNOS expressed in Escherichia coli by hemoglobin capture assay				Bioorg Med Chem 18: 6526-37 (2010) Article DOI: 10.1016/j.bmc.2010.06.074 BindingDB Entry DOI: 10.7270/Q26110HX
					More data for this Ligand-Target Pair