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BDBM50325475 1-(1-(4-(pyridin-4-ylmethyl)piperazine-1-carbonyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one::CHEMBL1222583

SMILES: O=C(N1CCC(CC1)n1c2ccccc2[nH]c1=O)N1CCN(Cc2ccncc2)CC1

InChI Key: InChIKey=FXVMTVXKBPDIKE-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50325475   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
HRH3


(GUINEA PIG)		BDBM50325475
PNG
(1-(1-(4-(pyridin-4-ylmethyl)piperazine-1-carbonyl)...)
Show SMILES O=C(N1CCC(CC1)n1c2ccccc2[nH]c1=O)N1CCN(Cc2ccncc2)CC1
Show InChI InChI=1S/C23H28N6O2/c30-22-25-20-3-1-2-4-21(20)29(22)19-7-11-27(12-8-19)23(31)28-15-13-26(14-16-28)17-18-5-9-24-10-6-18/h1-6,9-10,19H,7-8,11-17H2,(H,25,30)
UniProtKB/SwissProt

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PubMed
 17n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]Nalpha-methylhistamine from histamine H3 receptor in guinea pig brain

Bioorg Med Chem Lett 20: 5004-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.052
BindingDB Entry DOI: 10.7270/Q2N016QS
More data for this
Ligand-Target Pair