BDBM50326383 (2S)-1-({(2S,4S)-5-Oxo-4-[2-oxo-2-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]ethyl]pyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile::CHEMBL1243027

SMILES: FC(F)(F)c1nnc2CN(CCn12)C(=O)C[C@@H]1C[C@H](NC1=O)C(=O)N1CCC[C@H]1C#N

InChI Key: InChIKey=KITTXCKZJBJAGL-SRVKXCTJSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50326383   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast activation protein alpha (Homo sapiens (Human))	BDBM50326383 ((2S)-1-({(2S,4S)-5-Oxo-4-[2-oxo-2-[3-(trifluoromet...) Show SMILES FC(F)(F)c1nnc2CN(CCn12)C(=O)C[C@@H]1C[C@H](NC1=O)C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C18H20F3N7O3/c19-18(20,21)17-25-24-13-9-26(4-5-28(13)17)14(29)7-10-6-12(23-15(10)30)16(31)27-3-1-2-11(27)8-22/h10-12H,1-7,9H2,(H,23,30)/t10-,11-,12-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant FAP expressed in Hi5 insect cells				J Med Chem 53: 6572-83 (2010) Article DOI: 10.1021/jm1002556 BindingDB Entry DOI: 10.7270/Q23F4QM9
					More data for this Ligand-Target Pair
Dipeptidyl peptidase VIII (Homo sapiens (Human))	BDBM50326383 ((2S)-1-({(2S,4S)-5-Oxo-4-[2-oxo-2-[3-(trifluoromet...) Show SMILES FC(F)(F)c1nnc2CN(CCn12)C(=O)C[C@@H]1C[C@H](NC1=O)C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C18H20F3N7O3/c19-18(20,21)17-25-24-13-9-26(4-5-28(13)17)14(29)7-10-6-12(23-15(10)30)16(31)27-3-1-2-11(27)8-22/h10-12H,1-7,9H2,(H,23,30)/t10-,11-,12-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant His-tagged DPP8 expressed in insect cells				J Med Chem 53: 6572-83 (2010) Article DOI: 10.1021/jm1002556 BindingDB Entry DOI: 10.7270/Q23F4QM9
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50326383 ((2S)-1-({(2S,4S)-5-Oxo-4-[2-oxo-2-[3-(trifluoromet...) Show SMILES FC(F)(F)c1nnc2CN(CCn12)C(=O)C[C@@H]1C[C@H](NC1=O)C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C18H20F3N7O3/c19-18(20,21)17-25-24-13-9-26(4-5-28(13)17)14(29)7-10-6-12(23-15(10)30)16(31)27-3-1-2-11(27)8-22/h10-12H,1-7,9H2,(H,23,30)/t10-,11-,12-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant His-tagged DPP4 expressed in insect cells				J Med Chem 53: 6572-83 (2010) Article DOI: 10.1021/jm1002556 BindingDB Entry DOI: 10.7270/Q23F4QM9
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human))	BDBM50326383 ((2S)-1-({(2S,4S)-5-Oxo-4-[2-oxo-2-[3-(trifluoromet...) Show SMILES FC(F)(F)c1nnc2CN(CCn12)C(=O)C[C@@H]1C[C@H](NC1=O)C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C18H20F3N7O3/c19-18(20,21)17-25-24-13-9-26(4-5-28(13)17)14(29)7-10-6-12(23-15(10)30)16(31)27-3-1-2-11(27)8-22/h10-12H,1-7,9H2,(H,23,30)/t10-,11-,12-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant His-tagged DPP2 expressed in insect cells				J Med Chem 53: 6572-83 (2010) Article DOI: 10.1021/jm1002556 BindingDB Entry DOI: 10.7270/Q23F4QM9
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 9 (Homo sapiens (Human))	BDBM50326383 ((2S)-1-({(2S,4S)-5-Oxo-4-[2-oxo-2-[3-(trifluoromet...) Show SMILES FC(F)(F)c1nnc2CN(CCn12)C(=O)C[C@@H]1C[C@H](NC1=O)C(=O)N1CCC[C@H]1C#N |r| Show InChI InChI=1S/C18H20F3N7O3/c19-18(20,21)17-25-24-13-9-26(4-5-28(13)17)14(29)7-10-6-12(23-15(10)30)16(31)27-3-1-2-11(27)8-22/h10-12H,1-7,9H2,(H,23,30)/t10-,11-,12-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of human recombinant His-tagged DPP9 expressed in insect cells				J Med Chem 53: 6572-83 (2010) Article DOI: 10.1021/jm1002556 BindingDB Entry DOI: 10.7270/Q23F4QM9
					More data for this Ligand-Target Pair