BDBM50326959 1,1,1-Trifluoro-4-(4-methoxybiphenyl-3-yl)-4-methyl-2-(1H-pyrrolo[2,3-c]pyridin-2-ylmethyl)pentan-2-ol::CHEMBL1254080

SMILES: COc1ccc(cc1C(C)(C)CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)-c1ccccc1

InChI Key: InChIKey=BFWRCRIDNKRGTD-UHFFFAOYSA-N

Data: 4 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50326959   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50326959 (1,1,1-Trifluoro-4-(4-methoxybiphenyl-3-yl)-4-methy...) Show SMILES COc1ccc(cc1C(C)(C)CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)-c1ccccc1 Show InChI InChI=1S/C27H27F3N2O2/c1-25(2,22-14-19(9-10-24(22)34-3)18-7-5-4-6-8-18)17-26(33,27(28,29)30)15-21-13-20-11-12-31-16-23(20)32-21/h4-14,16,32-33H,15,17H2,1-3H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to glucocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by fluore...				J Med Chem 53: 6681-98 (2010) Article DOI: 10.1021/jm100751q BindingDB Entry DOI: 10.7270/Q2571D0X
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50326959 (1,1,1-Trifluoro-4-(4-methoxybiphenyl-3-yl)-4-methy...) Show SMILES COc1ccc(cc1C(C)(C)CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)-c1ccccc1 Show InChI InChI=1S/C27H27F3N2O2/c1-25(2,22-14-19(9-10-24(22)34-3)18-7-5-4-6-8-18)17-26(33,27(28,29)30)15-21-13-20-11-12-31-16-23(20)32-21/h4-14,16,32-33H,15,17H2,1-3H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	69	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Transactivation activity at glucocorticoid receptor in HFF assessed as induction of aromatase activity after 18 to 24 hrs by ELISA				J Med Chem 53: 6681-98 (2010) Article DOI: 10.1021/jm100751q BindingDB Entry DOI: 10.7270/Q2571D0X
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50326959 (1,1,1-Trifluoro-4-(4-methoxybiphenyl-3-yl)-4-methy...) Show SMILES COc1ccc(cc1C(C)(C)CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)-c1ccccc1 Show InChI InChI=1S/C27H27F3N2O2/c1-25(2,22-14-19(9-10-24(22)34-3)18-7-5-4-6-8-18)17-26(33,27(28,29)30)15-21-13-20-11-12-31-16-23(20)32-21/h4-14,16,32-33H,15,17H2,1-3H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Transrepression activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs by ELISA				J Med Chem 53: 6681-98 (2010) Article DOI: 10.1021/jm100751q BindingDB Entry DOI: 10.7270/Q2571D0X
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50326959 (1,1,1-Trifluoro-4-(4-methoxybiphenyl-3-yl)-4-methy...) Show SMILES COc1ccc(cc1C(C)(C)CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)-c1ccccc1 Show InChI InChI=1S/C27H27F3N2O2/c1-25(2,22-14-19(9-10-24(22)34-3)18-7-5-4-6-8-18)17-26(33,27(28,29)30)15-21-13-20-11-12-31-16-23(20)32-21/h4-14,16,32-33H,15,17H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to progesterone receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled RU-486 by fluorescence po...				J Med Chem 53: 6681-98 (2010) Article DOI: 10.1021/jm100751q BindingDB Entry DOI: 10.7270/Q2571D0X
					More data for this Ligand-Target Pair
Mineralocorticoid receptor (Homo sapiens (Human))	BDBM50326959 (1,1,1-Trifluoro-4-(4-methoxybiphenyl-3-yl)-4-methy...) Show SMILES COc1ccc(cc1C(C)(C)CC(O)(Cc1cc2ccncc2[nH]1)C(F)(F)F)-c1ccccc1 Show InChI InChI=1S/C27H27F3N2O2/c1-25(2,22-14-19(9-10-24(22)34-3)18-7-5-4-6-8-18)17-26(33,27(28,29)30)15-21-13-20-11-12-31-16-23(20)32-21/h4-14,16,32-33H,15,17H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer-Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to mineralocorticoid receptor expressed in baculovirus-infected insect cells using tetramethylrhodamine labeled Dexamethasone by flu...				J Med Chem 53: 6681-98 (2010) Article DOI: 10.1021/jm100751q BindingDB Entry DOI: 10.7270/Q2571D0X
					More data for this Ligand-Target Pair