BDBM50327005 CHEMBL1254427::N-Ethyl-4-(5-(2-methoxyethylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide

SMILES: CCNC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)NCCOC)c2c1C

InChI Key: InChIKey=DUPYSVBVDKGLCC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50327005   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50327005 (CHEMBL1254427 | N-Ethyl-4-(5-(2-methoxyethylcarbam...) Show SMILES CCNC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)NCCOC)c2c1C Show InChI InChI=1S/C21H26N6O3/c1-5-22-21(29)16-11-27-18(14(16)3)19(24-12-25-27)26-17-10-15(7-6-13(17)2)20(28)23-8-9-30-4/h6-7,10-12H,5,8-9H2,1-4H3,(H,22,29)(H,23,28)(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Inhibition of bacterially expressed p38alpha pretreated for 10 mins measured after 45 mins				J Med Chem 53: 6629-39 (2010) Article DOI: 10.1021/jm100540x BindingDB Entry DOI: 10.7270/Q2JM29T1
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