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SMILES: CCNC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)Nc3ncc(C)s3)c2c1C

InChI Key: InChIKey=OMHJGTNHFKDJLB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50327017   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50327017
PNG
(CHEMBL1254916 | N-Ethyl-5-methyl-4-(2-methyl-5-(5-...)
Show SMILES CCNC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)Nc3ncc(C)s3)c2c1C
Show InChI InChI=1S/C22H23N7O2S/c1-5-23-21(31)16-10-29-18(14(16)4)19(25-11-26-29)27-17-8-15(7-6-12(17)2)20(30)28-22-24-9-13(3)32-22/h6-11H,5H2,1-4H3,(H,23,31)(H,24,28,30)(H,25,26,27)
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Similars
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of bacterially expressed p38alpha pretreated for 10 mins measured after 45 mins

J Med Chem 53: 6629-39 (2010)


Article DOI: 10.1021/jm100540x
BindingDB Entry DOI: 10.7270/Q2JM29T1
More data for this
Ligand-Target Pair