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SMILES: Cc1ccc(cc1C(=O)NC1CCN(CCN2CCOCC2)CC1)-n1nc(cc1NC(=O)Nc1cccc2ccccc12)C(C)(C)C

InChI Key: InChIKey=BUANBTMUMFMMJA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50327199   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50327199
PNG
(5-(3-tert-butyl-5-(3-naphthalen-1-ylureido)-1H-pyr...)
Show SMILES Cc1ccc(cc1C(=O)NC1CCN(CCN2CCOCC2)CC1)-n1nc(cc1NC(=O)Nc1cccc2ccccc12)C(C)(C)C
Show InChI InChI=1S/C37H47N7O3/c1-26-12-13-29(24-31(26)35(45)38-28-14-16-42(17-15-28)18-19-43-20-22-47-23-21-43)44-34(25-33(41-44)37(2,3)4)40-36(46)39-32-11-7-9-27-8-5-6-10-30(27)32/h5-13,24-25,28H,14-23H2,1-4H3,(H,38,45)(H2,39,40,46)
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Article
PubMed
 885n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to full-length GST-tagged p38alpha after 2.5 hrs by TR-FRET competition binding assay

Bioorg Med Chem Lett 20: 5787-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.097
BindingDB Entry DOI: 10.7270/Q2MC907J
More data for this
Ligand-Target Pair