BindingDB logo
myBDB logout

BDBM50327201 CHEMBL1256040::N-(2-(1H-indol-3-yl)ethyl)-5-(3-tert-butyl-5-(3-naphthalen-1-ylureido)-1H-pyrazol-1-yl)-2-methylbenzamide

SMILES: Cc1ccc(cc1C(=O)NCCc1c[nH]c2ccccc12)-n1nc(cc1NC(=O)Nc1cccc2ccccc12)C(C)(C)C

InChI Key: InChIKey=YONPRXCCOCSOFX-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50327201   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50327201
PNG
(CHEMBL1256040 | N-(2-(1H-indol-3-yl)ethyl)-5-(3-te...)
Show SMILES Cc1ccc(cc1C(=O)NCCc1c[nH]c2ccccc12)-n1nc(cc1NC(=O)Nc1cccc2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H36N6O2/c1-23-16-17-26(20-29(23)34(43)37-19-18-25-22-38-30-14-8-7-13-28(25)30)42-33(21-32(41-42)36(2,3)4)40-35(44)39-31-15-9-11-24-10-5-6-12-27(24)31/h5-17,20-22,38H,18-19H2,1-4H3,(H,37,43)(H2,39,40,44)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.40E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to full-length GST-tagged p38alpha after 2.5 hrs by TR-FRET competition binding assay

Bioorg Med Chem Lett 20: 5787-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.04.097
BindingDB Entry DOI: 10.7270/Q2MC907J
More data for this
Ligand-Target Pair