Found 4 hits for monomerid = 50327976 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit
(Mus musculus) | BDBM50327976
(CHEMBL215476 | N-benzyl-N-(2-((4-cyanophenyl)((1-m...)Show SMILES Cn1cncc1CN(CCN(Cc1ccccc1)S(=O)(=O)c1ccccn1)c1ccc(cc1)C#N Show InChI InChI=1S/C26H26N6O2S/c1-30-21-28-18-25(30)20-31(24-12-10-22(17-27)11-13-24)15-16-32(19-23-7-3-2-4-8-23)35(33,34)26-9-5-6-14-29-26/h2-14,18,21H,15-16,19-20H2,1H3 | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of H-Ras farnesylation expressed in mouse NIH3T3 cells |
J Med Chem 53: 6867-88 (2010)
Article DOI: 10.1021/jm1001748 BindingDB Entry DOI: 10.7270/Q26110JC |
More data for this Ligand-Target Pair | |
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)
(Homo sapiens (Human)) | BDBM50327976
(CHEMBL215476 | N-benzyl-N-(2-((4-cyanophenyl)((1-m...)Show SMILES Cn1cncc1CN(CCN(Cc1ccccc1)S(=O)(=O)c1ccccn1)c1ccc(cc1)C#N Show InChI InChI=1S/C26H26N6O2S/c1-30-21-28-18-25(30)20-31(24-12-10-22(17-27)11-13-24)15-16-32(19-23-7-3-2-4-8-23)35(33,34)26-9-5-6-14-29-26/h2-14,18,21H,15-16,19-20H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of human geranylgeranyltransferase-1 assessed as incorporation of [3H]GGPP into H-Ras-CVLL |
J Med Chem 53: 6867-88 (2010)
Article DOI: 10.1021/jm1001748 BindingDB Entry DOI: 10.7270/Q26110JC |
More data for this Ligand-Target Pair | |
Protein Farnesyltransferase (PFT)
(Homo sapiens (Human)) | BDBM50327976
(CHEMBL215476 | N-benzyl-N-(2-((4-cyanophenyl)((1-m...)Show SMILES Cn1cncc1CN(CCN(Cc1ccccc1)S(=O)(=O)c1ccccn1)c1ccc(cc1)C#N Show InChI InChI=1S/C26H26N6O2S/c1-30-21-28-18-25(30)20-31(24-12-10-22(17-27)11-13-24)15-16-32(19-23-7-3-2-4-8-23)35(33,34)26-9-5-6-14-29-26/h2-14,18,21H,15-16,19-20H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLS |
J Med Chem 53: 6867-88 (2010)
Article DOI: 10.1021/jm1001748 BindingDB Entry DOI: 10.7270/Q26110JC |
More data for this Ligand-Target Pair | |
Geranylgeranyl transferase type 1
(Mus musculus) | BDBM50327976
(CHEMBL215476 | N-benzyl-N-(2-((4-cyanophenyl)((1-m...)Show SMILES Cn1cncc1CN(CCN(Cc1ccccc1)S(=O)(=O)c1ccccn1)c1ccc(cc1)C#N Show InChI InChI=1S/C26H26N6O2S/c1-30-21-28-18-25(30)20-31(24-12-10-22(17-27)11-13-24)15-16-32(19-23-7-3-2-4-8-23)35(33,34)26-9-5-6-14-29-26/h2-14,18,21H,15-16,19-20H2,1H3 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of Rap1A geranylgeranylation expressed in mouse NIH3T3 cells |
J Med Chem 53: 6867-88 (2010)
Article DOI: 10.1021/jm1001748 BindingDB Entry DOI: 10.7270/Q26110JC |
More data for this Ligand-Target Pair | |