BDBM50328074 CHEMBL1258919::N-(3-methoxyphenyl)-1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

SMILES: COc1cccc(Nc2nc(nc3n(C)ncc23)-c2cccnc2)c1

InChI Key: InChIKey=QYDZOQMWTHQDIL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50328074   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50328074 (CHEMBL1258919 | N-(3-methoxyphenyl)-1-methyl-6-(py...) Show SMILES COc1cccc(Nc2nc(nc3n(C)ncc23)-c2cccnc2)c1 Show InChI InChI=1S/C18H16N6O/c1-24-18-15(11-20-24)17(21-13-6-3-7-14(9-13)25-2)22-16(23-18)12-5-4-8-19-10-12/h3-11H,1-2H3,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha				Bioorg Med Chem Lett 20: 6048-51 (2010) Article DOI: 10.1016/j.bmcl.2010.08.067 BindingDB Entry DOI: 10.7270/Q2ST7Q28
					More data for this Ligand-Target Pair