BDBM50329267 (R)-2-(4-fluoro-3,5-dimethylphenylamino)-N-hydroxy-6-(4-methylbenzylamino)hexanamide::CHEMBL1270103
SMILES: Cc1ccc(CNCCCC[C@@H](Nc2cc(C)c(F)c(C)c2)C(=O)NO)cc1
InChI Key: InChIKey=WXSSZKMYHPTKFZ-HXUWFJFHSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Antrax lethal toxin (Bacillus anthracis) | BDBM50329267 ((R)-2-(4-fluoro-3,5-dimethylphenylamino)-N-hydroxy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
PanThera Biopharma, LLC Curated by ChEMBL | Assay Description Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate by FRET assay | Bioorg Med Chem Lett 20: 6850-3 (2010) Article DOI: 10.1016/j.bmcl.2010.08.058 BindingDB Entry DOI: 10.7270/Q2222V01 | |||||||||||
More data for this Ligand-Target Pair |