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BDBM50329377 4'-((3-(4-(dimethylamino)-1-hydroxy-1-phenylbutyl)phenoxy)methyl)biphenyl-4-carboxylic acid::CHEMBL1270820

SMILES: CN(C)CCCC(O)(c1ccccc1)c1cccc(OCc2ccc(cc2)-c2ccc(cc2)C(O)=O)c1

InChI Key: InChIKey=NHAWCIYWXIMWEF-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50329377   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM50329377
PNG
(4'-((3-(4-(dimethylamino)-1-hydroxy-1-phenylbutyl)...)
Show SMILES CN(C)CCCC(O)(c1ccccc1)c1cccc(OCc2ccc(cc2)-c2ccc(cc2)C(O)=O)c1
Show InChI InChI=1S/C32H33NO4/c1-33(2)21-7-20-32(36,28-8-4-3-5-9-28)29-10-6-11-30(22-29)37-23-24-12-14-25(15-13-24)26-16-18-27(19-17-26)31(34)35/h3-6,8-19,22,36H,7,20-21,23H2,1-2H3,(H,34,35)
PDB

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UniProtKB/TrEMBL

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Similars
Article
PubMed
 5.20E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay

Bioorg Med Chem Lett 20: 6587-91 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3
More data for this
Ligand-Target Pair