BDBM50329908 6-(4-(allyloxy)-5-ethyl-6-methylpyrimidin-2-yl)pyridin-3-amine::CHEMBL1269468

SMILES: CCc1c(C)nc(nc1OCC=C)-c1ccc(N)cn1

InChI Key: InChIKey=DNDWMGBJOGKNSP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50329908   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50329908 (6-(4-(allyloxy)-5-ethyl-6-methylpyrimidin-2-yl)pyr...) Show SMILES CCc1c(C)nc(nc1OCC=C)-c1ccc(N)cn1 Show InChI InChI=1S/C15H18N4O/c1-4-8-20-15-12(5-2)10(3)18-14(19-15)13-7-6-11(16)9-17-13/h4,6-7,9H,1,5,8,16H2,2-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Life Sciences Curated by ChEMBL					Assay Description Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assay				Bioorg Med Chem Lett 20: 6426-9 (2010) Article DOI: 10.1016/j.bmcl.2010.09.083 BindingDB Entry DOI: 10.7270/Q2HX1CXM
					More data for this Ligand-Target Pair