BDBM50330694 1-acetyl-4-methyl-2-phenyl-5-(pyridin-3-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione::CHEMBL1277397

SMILES: CC(=O)n1n(-c2ccccc2)c(=O)c2c(C)n(Cc3cccnc3)c(=O)cc12

InChI Key: InChIKey=LBGHHAWJKSAZHY-UHFFFAOYSA-N

Data: 1 KI

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50330694   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
NADPH oxidase 4 (Homo sapiens (Human))	BDBM50330694 (1-acetyl-4-methyl-2-phenyl-5-(pyridin-3-ylmethyl)-...) Show SMILES CC(=O)n1n(-c2ccccc2)c(=O)c2c(C)n(Cc3cccnc3)c(=O)cc12 Show InChI InChI=1S/C21H18N4O3/c1-14-20-18(11-19(27)23(14)13-16-7-6-10-22-12-16)24(15(2)26)25(21(20)28)17-8-4-3-5-9-17/h3-12H,13H2,1-2H3	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	409	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genkyotex, S.A. Curated by ChEMBL					Assay Description Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH				J Med Chem 53: 7715-30 (2010) Article DOI: 10.1021/jm100773e BindingDB Entry DOI: 10.7270/Q2KH0NKJ
					More data for this Ligand-Target Pair