BDBM50331433 CHEMBL1289067::N-{3-[(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-pyrimidin-2-yl-amino]-propyl}-4-fluoro-benzamide

SMILES: Fc1ccc(cc1)C(=O)NCCCN(C1=NS(=O)(=O)c2ccccc12)c1ncccn1

InChI Key: InChIKey=IEQDZTJRBUUWGU-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331433   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50331433 (CHEMBL1289067 | N-{3-[(1,1-Dioxo-1H-1lambda*6*-ben...) Show SMILES Fc1ccc(cc1)C(=O)NCCCN(C1=NS(=O)(=O)c2ccccc12)c1ncccn1 |t:15| Show InChI InChI=1S/C21H18FN5O3S/c22-16-9-7-15(8-10-16)20(28)23-13-4-14-27(21-24-11-3-12-25-21)19-17-5-1-2-6-18(17)31(29,30)26-19/h1-3,5-12H,4,13-14H2,(H,23,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Inhibition of human voltage-gated potassium channel Kv1.3 expressed in CGE22 cells by patch clamp assay				Bioorg Med Chem Lett 20: 6983-8 (2010) Article DOI: 10.1016/j.bmcl.2010.09.132 BindingDB Entry DOI: 10.7270/Q2N58MMS
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