BDBM50331435 CHEMBL1290505::N-{3-[(3,5-Difluoro-phenyl)-(1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazo l-3-yl)-amino]-propyl}-4-fluoro-benzamide

SMILES: Fc1ccc(cc1)C(=O)NCCCN(C1=NS(=O)(=O)c2ccccc12)c1cc(F)cc(F)c1

InChI Key: InChIKey=HRTQYHJIPREZOA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331435   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50331435 (CHEMBL1290505 | N-{3-[(3,5-Difluoro-phenyl)-(1,1-d...) Show SMILES Fc1ccc(cc1)C(=O)NCCCN(C1=NS(=O)(=O)c2ccccc12)c1cc(F)cc(F)c1 |t:15| Show InChI InChI=1S/C23H18F3N3O3S/c24-16-8-6-15(7-9-16)23(30)27-10-3-11-29(19-13-17(25)12-18(26)14-19)22-20-4-1-2-5-21(20)33(31,32)28-22/h1-2,4-9,12-14H,3,10-11H2,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.47E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Inhibition of human voltage-gated potassium channel Kv1.3 expressed in CGE22 cells by patch clamp assay				Bioorg Med Chem Lett 20: 6983-8 (2010) Article DOI: 10.1016/j.bmcl.2010.09.132 BindingDB Entry DOI: 10.7270/Q2N58MMS
					More data for this Ligand-Target Pair