BindingDB logo
myBDB logout

null

SMILES: O=c1[nH]ccc2nc(NCc3ccncc3)c(cc12)-c1ccccc1

InChI Key: InChIKey=KRBUNJKMPNSZEH-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331810   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50331810
PNG
(3-phenyl-2-(pyridin-4-ylmethylamino)-1,6-naphthyri...)
Show SMILES O=c1[nH]ccc2nc(NCc3ccncc3)c(cc12)-c1ccccc1
Show InChI InChI=1S/C20H16N4O/c25-20-17-12-16(15-4-2-1-3-5-15)19(24-18(17)8-11-22-20)23-13-14-6-9-21-10-7-14/h1-12H,13H2,(H,22,25)(H,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of JAK2 in cell-free system

Bioorg Med Chem Lett 20: 7421-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.031
BindingDB Entry DOI: 10.7270/Q2SQ90MG
More data for this
Ligand-Target Pair