BDBM50331818 6-(3-amino-2,2-dimethylpropylamino)-9-fluorobenzo[c][1,6]naphthyridin-1(2H)-one::CHEMBL1290310

SMILES: CC(C)(CN)CNc1nc2cc[nH]c(=O)c2c2cc(F)ccc12

InChI Key: InChIKey=IPJLUAGVDVCCQR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331818   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50331818 (6-(3-amino-2,2-dimethylpropylamino)-9-fluorobenzo[...) Show SMILES CC(C)(CN)CNc1nc2cc[nH]c(=O)c2c2cc(F)ccc12 Show InChI InChI=1S/C17H19FN4O/c1-17(2,8-19)9-21-15-11-4-3-10(18)7-12(11)14-13(22-15)5-6-20-16(14)23/h3-7H,8-9,19H2,1-2H3,(H,20,23)(H,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of JAK2 in cell-free system				Bioorg Med Chem Lett 20: 7421-5 (2010) Article DOI: 10.1016/j.bmcl.2010.10.031 BindingDB Entry DOI: 10.7270/Q2SQ90MG
					More data for this Ligand-Target Pair