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SMILES: Fc1ccc2c(NCc3ccccn3)nc3cc[nH]c(=O)c3c2c1

InChI Key: InChIKey=NKVMMNLSDVEDCO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331820   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50331820
PNG
(9-fluoro-6-(pyridin-2-ylmethylamino)benzo[c][1,6]n...)
Show SMILES Fc1ccc2c(NCc3ccccn3)nc3cc[nH]c(=O)c3c2c1
Show InChI InChI=1S/C18H13FN4O/c19-11-4-5-13-14(9-11)16-15(6-8-21-18(16)24)23-17(13)22-10-12-3-1-2-7-20-12/h1-9H,10H2,(H,21,24)(H,22,23)
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n/an/a 1.12E+3n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of JAK2 in cell-free system

Bioorg Med Chem Lett 20: 7421-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.031
BindingDB Entry DOI: 10.7270/Q2SQ90MG
More data for this
Ligand-Target Pair