BDBM50331826 9-fluoro-6-((7R)-1,6,6-trimethylbicyclo[3.1.1]heptan-7-ylamino)benzo[c][1,6]naphthyridin-1(2H)-one::CHEMBL1290768

SMILES: CC1(C)C2CCCC1(C)[C@@H]2Nc1nc2cc[nH]c(=O)c2c2cc(F)ccc12

InChI Key: InChIKey=FFSCPZBJYXHNHZ-GXPWMBGSSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331826   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50331826 (9-fluoro-6-((7R)-1,6,6-trimethylbicyclo[3.1.1]hept...) Show SMILES CC1(C)C2CCCC1(C)[C@@H]2Nc1nc2cc[nH]c(=O)c2c2cc(F)ccc12 |r| Show InChI InChI=1S/C22H24FN3O/c1-21(2)15-5-4-9-22(21,3)18(15)26-19-13-7-6-12(23)11-14(13)17-16(25-19)8-10-24-20(17)27/h6-8,10-11,15,18H,4-5,9H2,1-3H3,(H,24,27)(H,25,26)/t15?,18-,22?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of JAK2 in cell-free system				Bioorg Med Chem Lett 20: 7421-5 (2010) Article DOI: 10.1016/j.bmcl.2010.10.031 BindingDB Entry DOI: 10.7270/Q2SQ90MG
					More data for this Ligand-Target Pair