BDBM50332376 4-Amino-N-propyl-8-(pyrimidin-2-yl)cinnoline-3-carboxamide::CHEMBL1631468

SMILES: CCCNC(=O)c1nnc2c(cccc2c1N)-c1ncccn1

InChI Key: InChIKey=LHKDIYKHGIOMPL-UHFFFAOYSA-N

Data: 1 KI  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50332376   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GABA receptor alpha-2/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50332376 (4-Amino-N-propyl-8-(pyrimidin-2-yl)cinnoline-3-car...) Show SMILES CCCNC(=O)c1nnc2c(cccc2c1N)-c1ncccn1 Show InChI InChI=1S/C16H16N6O/c1-2-7-20-16(23)14-12(17)10-5-3-6-11(13(10)21-22-14)15-18-8-4-9-19-15/h3-6,8-9H,2,7H2,1H3,(H2,17,21)(H,20,23)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]flunitrazepam from human alpha2beta3gamma2 GABA receptor in Sf9 membranes after 1 hr by liquid scintillation counting				Bioorg Med Chem 18: 8374-82 (2010) Article DOI: 10.1016/j.bmc.2010.09.058 BindingDB Entry DOI: 10.7270/Q2FB536X
					More data for this Ligand-Target Pair
GABA receptor alpha-5/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50332376 (4-Amino-N-propyl-8-(pyrimidin-2-yl)cinnoline-3-car...) Show SMILES CCCNC(=O)c1nnc2c(cccc2c1N)-c1ncccn1 Show InChI InChI=1S/C16H16N6O/c1-2-7-20-16(23)14-12(17)10-5-3-6-11(13(10)21-22-14)15-18-8-4-9-19-15/h3-6,8-9H,2,7H2,1H3,(H2,17,21)(H,20,23)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.13E+3	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Binding affinity to human alpha5beta3gamma2 GABA receptor expressed in Xenopus laevis oocytes				Bioorg Med Chem 18: 8374-82 (2010) Article DOI: 10.1016/j.bmc.2010.09.058 BindingDB Entry DOI: 10.7270/Q2FB536X
					More data for this Ligand-Target Pair
GABA receptor alpha-3/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50332376 (4-Amino-N-propyl-8-(pyrimidin-2-yl)cinnoline-3-car...) Show SMILES CCCNC(=O)c1nnc2c(cccc2c1N)-c1ncccn1 Show InChI InChI=1S/C16H16N6O/c1-2-7-20-16(23)14-12(17)10-5-3-6-11(13(10)21-22-14)15-18-8-4-9-19-15/h3-6,8-9H,2,7H2,1H3,(H2,17,21)(H,20,23)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	379	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Binding affinity to human alpha3beta3gamma2 GABA receptor expressed in Xenopus laevis oocytes				Bioorg Med Chem 18: 8374-82 (2010) Article DOI: 10.1016/j.bmc.2010.09.058 BindingDB Entry DOI: 10.7270/Q2FB536X
					More data for this Ligand-Target Pair
GABA receptor alpha-2/beta-3/gamma-2 subunit (Homo sapiens (Human))	BDBM50332376 (4-Amino-N-propyl-8-(pyrimidin-2-yl)cinnoline-3-car...) Show SMILES CCCNC(=O)c1nnc2c(cccc2c1N)-c1ncccn1 Show InChI InChI=1S/C16H16N6O/c1-2-7-20-16(23)14-12(17)10-5-3-6-11(13(10)21-22-14)15-18-8-4-9-19-15/h3-6,8-9H,2,7H2,1H3,(H2,17,21)(H,20,23)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	104	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Binding affinity to human alpha2beta3gamma2 GABA receptor expressed in Xenopus laevis oocytes				Bioorg Med Chem 18: 8374-82 (2010) Article DOI: 10.1016/j.bmc.2010.09.058 BindingDB Entry DOI: 10.7270/Q2FB536X
					More data for this Ligand-Target Pair