BDBM50332860 (S)-2-(3-(dimethylamino)pyrrolidin-1-yl)-N-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-4-amine::CHEMBL1630624

SMILES: CN(C)[C@H]1CCN(C1)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F

InChI Key: InChIKey=PKILCYFBQFTXGK-IBGZPJMESA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50332860   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vanilloid receptor (Rattus norvegicus (rat))	BDBM50332860 ((S)-2-(3-(dimethylamino)pyrrolidin-1-yl)-N-(4-(tri...) Show SMILES CN(C)[C@H]1CCN(C1)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F |r| Show InChI InChI=1S/C27H29F6N7/c1-38(2)19-9-13-40(16-19)25-36-22-11-15-39(24-21(27(31,32)33)4-3-12-34-24)14-10-20(22)23(37-25)35-18-7-5-17(6-8-18)26(28,29)30/h3-8,12,19H,9-11,13-16H2,1-2H3,(H,35,36,37)/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	586	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research and Development LLC Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level by FLIPR assay				Bioorg Med Chem Lett 20: 7142-6 (2010) Article DOI: 10.1016/j.bmcl.2010.09.006 BindingDB Entry DOI: 10.7270/Q26Q1XH0
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50332860 ((S)-2-(3-(dimethylamino)pyrrolidin-1-yl)-N-(4-(tri...) Show SMILES CN(C)[C@H]1CCN(C1)c1nc2CCN(CCc2c(Nc2ccc(cc2)C(F)(F)F)n1)c1ncccc1C(F)(F)F |r| Show InChI InChI=1S/C27H29F6N7/c1-38(2)19-9-13-40(16-19)25-36-22-11-15-39(24-21(27(31,32)33)4-3-12-34-24)14-10-20(22)23(37-25)35-18-7-5-17(6-8-18)26(28,29)30/h3-8,12,19H,9-11,13-16H2,1-2H3,(H,35,36,37)/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	185	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research and Development LLC Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level by FLIPR assay				Bioorg Med Chem Lett 20: 7142-6 (2010) Article DOI: 10.1016/j.bmcl.2010.09.006 BindingDB Entry DOI: 10.7270/Q26Q1XH0
					More data for this Ligand-Target Pair