BDBM50332871 CHEMBL1631259::N2-(pyridin-2-ylmethyl)-N4-(4-(trifluoromethyl)phenyl)-7-(3-(trifluoromethyl)pyridin-2-yl)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepine-2,4-diamine

SMILES: FC(F)(F)c1ccc(Nc2nc(NCc3ccccn3)nc3CCN(CCc23)c2ncccc2C(F)(F)F)cc1

InChI Key: InChIKey=HULIPYRTZHBHFC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50332871   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vanilloid receptor (Rattus norvegicus (rat))	BDBM50332871 (CHEMBL1631259 | N2-(pyridin-2-ylmethyl)-N4-(4-(tri...) Show SMILES FC(F)(F)c1ccc(Nc2nc(NCc3ccccn3)nc3CCN(CCc23)c2ncccc2C(F)(F)F)cc1 Show InChI InChI=1S/C27H23F6N7/c28-26(29,30)17-6-8-18(9-7-17)37-23-20-10-14-40(24-21(27(31,32)33)5-3-13-35-24)15-11-22(20)38-25(39-23)36-16-19-4-1-2-12-34-19/h1-9,12-13H,10-11,14-16H2,(H2,36,37,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research and Development LLC Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level by FLIPR assay				Bioorg Med Chem Lett 20: 7142-6 (2010) Article DOI: 10.1016/j.bmcl.2010.09.006 BindingDB Entry DOI: 10.7270/Q26Q1XH0
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50332871 (CHEMBL1631259 | N2-(pyridin-2-ylmethyl)-N4-(4-(tri...) Show SMILES FC(F)(F)c1ccc(Nc2nc(NCc3ccccn3)nc3CCN(CCc23)c2ncccc2C(F)(F)F)cc1 Show InChI InChI=1S/C27H23F6N7/c28-26(29,30)17-6-8-18(9-7-17)37-23-20-10-14-40(24-21(27(31,32)33)5-3-13-35-24)15-11-22(20)38-25(39-23)36-16-19-4-1-2-12-34-19/h1-9,12-13H,10-11,14-16H2,(H2,36,37,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	476	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research and Development LLC Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level by FLIPR assay				Bioorg Med Chem Lett 20: 7142-6 (2010) Article DOI: 10.1016/j.bmcl.2010.09.006 BindingDB Entry DOI: 10.7270/Q26Q1XH0
					More data for this Ligand-Target Pair