BDBM50333474 2-(3-1H-indazol-5-ylureido)-5-tert-butylthiophene-3-carboxylic acid::CHEMBL1641799

SMILES: CC(C)(C)c1cc(C(O)=O)c(NC(=O)Nc2ccc3[nH]ncc3c2)s1

InChI Key: InChIKey=BSRFCMMJUFQEOX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50333474   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ribosomal protein S6 kinase (P70S6K) (Homo sapiens (Human))	BDBM50333474 (2-(3-1H-indazol-5-ylureido)-5-tert-butylthiophene-...) Show SMILES CC(C)(C)c1cc(C(O)=O)c(NC(=O)Nc2ccc3[nH]ncc3c2)s1 Show InChI InChI=1S/C17H18N4O3S/c1-17(2,3)13-7-11(15(22)23)14(25-13)20-16(24)19-10-4-5-12-9(6-10)8-18-21-12/h4-8H,1-3H3,(H,18,21)(H,22,23)(H2,19,20,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of S6K1				Bioorg Med Chem Lett 21: 849-52 (2011) Article DOI: 10.1016/j.bmcl.2010.11.069 BindingDB Entry DOI: 10.7270/Q289163D
					More data for this Ligand-Target Pair