BDBM50333490 1-[5-tert-Butyl-3-(1,1-dioxo-1lambda*6*-thiomorpholine-4-carbonyl)-thiophen-2-yl]-3-[4-(pyridin-4-yloxy)-phenyl]-urea::CHEMBL1641783

SMILES: CC(C)(C)c1cc(C(=O)N2CCS(=O)(=O)CC2)c(NC(=O)Nc2ccc(Oc3ccncc3)cc2)s1

InChI Key: InChIKey=PHUFFFZBIRHVHZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50333490   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ribosomal protein S6 kinase (P70S6K) (Homo sapiens (Human))	BDBM50333490 (1-[5-tert-Butyl-3-(1,1-dioxo-1lambda*6*-thiomorpho...) Show SMILES CC(C)(C)c1cc(C(=O)N2CCS(=O)(=O)CC2)c(NC(=O)Nc2ccc(Oc3ccncc3)cc2)s1 Show InChI InChI=1S/C25H28N4O5S2/c1-25(2,3)21-16-20(23(30)29-12-14-36(32,33)15-13-29)22(35-21)28-24(31)27-17-4-6-18(7-5-17)34-19-8-10-26-11-9-19/h4-11,16H,12-15H2,1-3H3,(H2,27,28,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of S6K1				Bioorg Med Chem Lett 21: 849-52 (2011) Article DOI: 10.1016/j.bmcl.2010.11.069 BindingDB Entry DOI: 10.7270/Q289163D
					More data for this Ligand-Target Pair