Found 11 hits for monomerid = 50333748 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50333748
(CHEMBL1644003 | N,N,5,7-tetramethyl-3-(4-(2-(3-tos...)Show SMILES CN(C)C(=O)c1sc2c(C)cc(C)cc2c1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1 Show InChI InChI=1S/C29H31N3O4S2/c1-18-6-12-23(13-7-18)38(35,36)31-29(34)30-15-14-21-8-10-22(11-9-21)25-24-17-19(2)16-20(3)26(24)37-27(25)28(33)32(4)5/h6-13,16-17H,14-15H2,1-5H3,(H2,30,31,34) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.540 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Binding affinity to EP4 receptor |
Bioorg Med Chem Lett 21: 734-7 (2011)
Article DOI: 10.1016/j.bmcl.2010.11.118 BindingDB Entry DOI: 10.7270/Q22N52JP |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50333748
(CHEMBL1644003 | N,N,5,7-tetramethyl-3-(4-(2-(3-tos...)Show SMILES CN(C)C(=O)c1sc2c(C)cc(C)cc2c1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1 Show InChI InChI=1S/C29H31N3O4S2/c1-18-6-12-23(13-7-18)38(35,36)31-29(34)30-15-14-21-8-10-22(11-9-21)25-24-17-19(2)16-20(3)26(24)37-27(25)28(33)32(4)5/h6-13,16-17H,14-15H2,1-5H3,(H2,30,31,34) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Binding affinity to EP4 receptor in presence of 10% HSA |
Bioorg Med Chem Lett 21: 734-7 (2011)
Article DOI: 10.1016/j.bmcl.2010.11.118 BindingDB Entry DOI: 10.7270/Q22N52JP |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50333748
(CHEMBL1644003 | N,N,5,7-tetramethyl-3-(4-(2-(3-tos...)Show SMILES CN(C)C(=O)c1sc2c(C)cc(C)cc2c1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1 Show InChI InChI=1S/C29H31N3O4S2/c1-18-6-12-23(13-7-18)38(35,36)31-29(34)30-15-14-21-8-10-22(11-9-21)25-24-17-19(2)16-20(3)26(24)37-27(25)28(33)32(4)5/h6-13,16-17H,14-15H2,1-5H3,(H2,30,31,34) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Ratio of Ki for EP4 receptor to EP4 receptor in presence of 10% HSA |
Bioorg Med Chem Lett 21: 734-7 (2011)
Article DOI: 10.1016/j.bmcl.2010.11.118 BindingDB Entry DOI: 10.7270/Q22N52JP |
More data for this Ligand-Target Pair | |
Prostanoid TP receptor
(Homo sapiens (Human)) | BDBM50333748
(CHEMBL1644003 | N,N,5,7-tetramethyl-3-(4-(2-(3-tos...)Show SMILES CN(C)C(=O)c1sc2c(C)cc(C)cc2c1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1 Show InChI InChI=1S/C29H31N3O4S2/c1-18-6-12-23(13-7-18)38(35,36)31-29(34)30-15-14-21-8-10-22(11-9-21)25-24-17-19(2)16-20(3)26(24)37-27(25)28(33)32(4)5/h6-13,16-17H,14-15H2,1-5H3,(H2,30,31,34) | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Binding affinity to TP receptor |
Bioorg Med Chem Lett 21: 734-7 (2011)
Article DOI: 10.1016/j.bmcl.2010.11.118 BindingDB Entry DOI: 10.7270/Q22N52JP |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor
(Homo sapiens (Human)) | BDBM50333748
(CHEMBL1644003 | N,N,5,7-tetramethyl-3-(4-(2-(3-tos...)Show SMILES CN(C)C(=O)c1sc2c(C)cc(C)cc2c1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1 Show InChI InChI=1S/C29H31N3O4S2/c1-18-6-12-23(13-7-18)38(35,36)31-29(34)30-15-14-21-8-10-22(11-9-21)25-24-17-19(2)16-20(3)26(24)37-27(25)28(33)32(4)5/h6-13,16-17H,14-15H2,1-5H3,(H2,30,31,34) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Binding affinity to EP3 receptor |
Bioorg Med Chem Lett 21: 734-7 (2011)
Article DOI: 10.1016/j.bmcl.2010.11.118 BindingDB Entry DOI: 10.7270/Q22N52JP |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50333748
(CHEMBL1644003 | N,N,5,7-tetramethyl-3-(4-(2-(3-tos...)Show SMILES CN(C)C(=O)c1sc2c(C)cc(C)cc2c1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1 Show InChI InChI=1S/C29H31N3O4S2/c1-18-6-12-23(13-7-18)38(35,36)31-29(34)30-15-14-21-8-10-22(11-9-21)25-24-17-19(2)16-20(3)26(24)37-27(25)28(33)32(4)5/h6-13,16-17H,14-15H2,1-5H3,(H2,30,31,34) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Binding affinity to EP2 receptor |
Bioorg Med Chem Lett 21: 734-7 (2011)
Article DOI: 10.1016/j.bmcl.2010.11.118 BindingDB Entry DOI: 10.7270/Q22N52JP |
More data for this Ligand-Target Pair | |
G protein-coupled receptor 44
(Homo sapiens (Human)) | BDBM50333748
(CHEMBL1644003 | N,N,5,7-tetramethyl-3-(4-(2-(3-tos...)Show SMILES CN(C)C(=O)c1sc2c(C)cc(C)cc2c1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1 Show InChI InChI=1S/C29H31N3O4S2/c1-18-6-12-23(13-7-18)38(35,36)31-29(34)30-15-14-21-8-10-22(11-9-21)25-24-17-19(2)16-20(3)26(24)37-27(25)28(33)32(4)5/h6-13,16-17H,14-15H2,1-5H3,(H2,30,31,34) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >7.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Binding affinity to CRTH2 receptor |
Bioorg Med Chem Lett 21: 734-7 (2011)
Article DOI: 10.1016/j.bmcl.2010.11.118 BindingDB Entry DOI: 10.7270/Q22N52JP |
More data for this Ligand-Target Pair | |
Prostanoid IP receptor
(Homo sapiens (Human)) | BDBM50333748
(CHEMBL1644003 | N,N,5,7-tetramethyl-3-(4-(2-(3-tos...)Show SMILES CN(C)C(=O)c1sc2c(C)cc(C)cc2c1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1 Show InChI InChI=1S/C29H31N3O4S2/c1-18-6-12-23(13-7-18)38(35,36)31-29(34)30-15-14-21-8-10-22(11-9-21)25-24-17-19(2)16-20(3)26(24)37-27(25)28(33)32(4)5/h6-13,16-17H,14-15H2,1-5H3,(H2,30,31,34) | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >7.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Binding affinity to IP receptor |
Bioorg Med Chem Lett 21: 734-7 (2011)
Article DOI: 10.1016/j.bmcl.2010.11.118 BindingDB Entry DOI: 10.7270/Q22N52JP |
More data for this Ligand-Target Pair | |
Prostaglandin F2-alpha receptor
(Homo sapiens (Human)) | BDBM50333748
(CHEMBL1644003 | N,N,5,7-tetramethyl-3-(4-(2-(3-tos...)Show SMILES CN(C)C(=O)c1sc2c(C)cc(C)cc2c1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1 Show InChI InChI=1S/C29H31N3O4S2/c1-18-6-12-23(13-7-18)38(35,36)31-29(34)30-15-14-21-8-10-22(11-9-21)25-24-17-19(2)16-20(3)26(24)37-27(25)28(33)32(4)5/h6-13,16-17H,14-15H2,1-5H3,(H2,30,31,34) | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Binding affinity to FP receptor |
Bioorg Med Chem Lett 21: 734-7 (2011)
Article DOI: 10.1016/j.bmcl.2010.11.118 BindingDB Entry DOI: 10.7270/Q22N52JP |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype (EP1)
(Homo sapiens (Human)) | BDBM50333748
(CHEMBL1644003 | N,N,5,7-tetramethyl-3-(4-(2-(3-tos...)Show SMILES CN(C)C(=O)c1sc2c(C)cc(C)cc2c1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1 Show InChI InChI=1S/C29H31N3O4S2/c1-18-6-12-23(13-7-18)38(35,36)31-29(34)30-15-14-21-8-10-22(11-9-21)25-24-17-19(2)16-20(3)26(24)37-27(25)28(33)32(4)5/h6-13,16-17H,14-15H2,1-5H3,(H2,30,31,34) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Binding affinity to EP1 receptor |
Bioorg Med Chem Lett 21: 734-7 (2011)
Article DOI: 10.1016/j.bmcl.2010.11.118 BindingDB Entry DOI: 10.7270/Q22N52JP |
More data for this Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50333748
(CHEMBL1644003 | N,N,5,7-tetramethyl-3-(4-(2-(3-tos...)Show SMILES CN(C)C(=O)c1sc2c(C)cc(C)cc2c1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1 Show InChI InChI=1S/C29H31N3O4S2/c1-18-6-12-23(13-7-18)38(35,36)31-29(34)30-15-14-21-8-10-22(11-9-21)25-24-17-19(2)16-20(3)26(24)37-27(25)28(33)32(4)5/h6-13,16-17H,14-15H2,1-5H3,(H2,30,31,34) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Antagonist activity at human EP4 receptor in HEK293 cells by cell-based functional assay |
Bioorg Med Chem Lett 21: 734-7 (2011)
Article DOI: 10.1016/j.bmcl.2010.11.118 BindingDB Entry DOI: 10.7270/Q22N52JP |
More data for this Ligand-Target Pair | |