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SMILES: O=C(N1CCN(CC1)c1ccncn1)c1cccc(c1)C#Cc1ccccc1

InChI Key: InChIKey=RNMLLVAVDXVWJE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50334124   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50334124
PNG
((3-(phenylethynyl)phenyl)(4-(pyrimidin-4-yl)pipera...)
Show SMILES O=C(N1CCN(CC1)c1ccncn1)c1cccc(c1)C#Cc1ccccc1
Show InChI InChI=1S/C23H20N4O/c28-23(27-15-13-26(14-16-27)22-11-12-24-18-25-22)21-8-4-7-20(17-21)10-9-19-5-2-1-3-6-19/h1-8,11-12,17-18H,13-16H2
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MMDB

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 451n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MPEP from rat mGluR5 expressed in HEK293 cells

Bioorg Med Chem Lett 21: 195-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.038
BindingDB Entry DOI: 10.7270/Q2GQ6Z02
More data for this
Ligand-Target Pair