BDBM50334179 5-(naphthalen-1-ylmethylene)thiazolidine-2,4-dione::CHEMBL1348329::US10278929, Compound 13

SMILES: O=C1NC(=O)\C(S1)=C\c1cccc2ccccc12

InChI Key: InChIKey=WMHVUSFNJBJQQB-WQLSENKSSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50334179   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transthyretin (Homo sapiens (Human))	BDBM50334179 (5-(naphthalen-1-ylmethylene)thiazolidine-2,4-dione...) Show SMILES O=C1NC(=O)\C(S1)=C\c1cccc2ccccc12 Show InChI InChI=1S/C14H9NO2S/c16-13-12(18-14(17)15-13)8-10-6-3-5-9-4-1-2-7-11(9)10/h1-8H,(H,15,16,17)/b12-8-	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	842	n/a	n/a	n/a	n/a	n/a	n/a
The Board of Trustees of the Leland Stanford Junior University US Patent					Assay Description The FP assay was then adapted for HTS and used to screen ~120,000 small molecule library for compounds that displaced probe 5 from the T4 binding of ...				US Patent US8877795 (2014) BindingDB Entry DOI: 10.7270/Q2HT2N1M
					More data for this Ligand-Target Pair
Aldose reductase (AR) (Homo sapiens (Human))	BDBM50334179 (5-(naphthalen-1-ylmethylene)thiazolidine-2,4-dione...) Show SMILES O=C1NC(=O)\C(S1)=C\c1cccc2ccccc12 Show InChI InChI=1S/C14H9NO2S/c16-13-12(18-14(17)15-13)8-10-6-3-5-9-4-1-2-7-11(9)10/h1-8H,(H,15,16,17)/b12-8-	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.07E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Messina Curated by ChEMBL					Assay Description Inhibition of aldose reductase				Bioorg Med Chem Lett 21: 200-3 (2010) Article DOI: 10.1016/j.bmcl.2010.11.041 BindingDB Entry DOI: 10.7270/Q2ZP46C4
					More data for this Ligand-Target Pair
Aldose reductase (Homo sapiens (Human))	BDBM50334179 (5-(naphthalen-1-ylmethylene)thiazolidine-2,4-dione...) Show SMILES O=C1NC(=O)\C(S1)=C\c1cccc2ccccc12 Show InChI InChI=1S/C14H9NO2S/c16-13-12(18-14(17)15-13)8-10-6-3-5-9-4-1-2-7-11(9)10/h1-8H,(H,15,16,17)/b12-8-	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of aldose reductase (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-007-9061-4 BindingDB Entry DOI: 10.7270/Q2GB26Z6
					More data for this Ligand-Target Pair
Aldose reductase (Homo sapiens (Human))	BDBM50334179 (5-(naphthalen-1-ylmethylene)thiazolidine-2,4-dione...) Show SMILES O=C1NC(=O)\C(S1)=C\c1cccc2ccccc12 Show InChI InChI=1S/C14H9NO2S/c16-13-12(18-14(17)15-13)8-10-6-3-5-9-4-1-2-7-11(9)10/h1-8H,(H,15,16,17)/b12-8-	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	8.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of aldose reductase (unknown origin)				Citation and Details Article DOI: 10.1007/s00044-007-9061-4 BindingDB Entry DOI: 10.7270/Q2GB26Z6
					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50334179 (5-(naphthalen-1-ylmethylene)thiazolidine-2,4-dione...) Show SMILES O=C1NC(=O)\C(S1)=C\c1cccc2ccccc12 Show InChI InChI=1S/C14H9NO2S/c16-13-12(18-14(17)15-13)8-10-6-3-5-9-4-1-2-7-11(9)10/h1-8H,(H,15,16,17)/b12-8-	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	842	n/a	n/a	n/a	n/a	n/a	n/a
IRBM/Merck					Assay Description The FP assay was then adapted for HTS and used to screen a ˜120,000 member small molecule library for compounds that displaced the FP probe from the ...				Bioorg Med Chem Lett 18: 3456-61 (2008) BindingDB Entry DOI: 10.7270/Q2H70J43
					More data for this Ligand-Target Pair