BDBM50334849 CHEMBL1643236::Syn-5-((3-aminocyclohexyl)methyl)-6-bromo-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine
SMILES: Cn1cc(cn1)-c1cnn2c(N)c(Br)c(C[C@H]3CCC[C@@H](N)C3)nc12
InChI Key: InChIKey=WFPIRVVONIIHDU-CMPLNLGQSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM50334849![]() (CHEMBL1643236 | Syn-5-((3-aminocyclohexyl)methyl)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of histidine-tagged recombinant CHK1 expressed in baculovirus expression system after 2 hrs by scintillation proximity assay | Bioorg Med Chem Lett 21: 471-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.114 BindingDB Entry DOI: 10.7270/Q2P26ZC9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK2/Cyclin A/Cyclin A1 (Homo sapiens (Human)) | BDBM50334849![]() (CHEMBL1643236 | Syn-5-((3-aminocyclohexyl)methyl)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of recombinant CDK2/Cyclin A expressed in insect Sf9 cells assessed as inhibition of [33P]-ATP incorporation into biotinylated histone H1 ... | Bioorg Med Chem Lett 21: 471-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.114 BindingDB Entry DOI: 10.7270/Q2P26ZC9 | |||||||||||
More data for this Ligand-Target Pair |