BDBM50335166 2-(5-(2-(Trifluoromethyl)phenyl)-1H-benzo[d]imidazol-2-yl)-3-oxa-1-azaspiro[4.5]dec-1-ene::CHEMBL1650508

SMILES: FC(F)(F)c1ccccc1-c1ccc2nc([nH]c2c1)C1=NC2(CO1)CCCCC2

InChI Key: InChIKey=GDGLSBUBONLKDB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50335166   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential M8 protein (TRPM8) (Canis lupus familiaris (Dog))	BDBM50335166 (2-(5-(2-(Trifluoromethyl)phenyl)-1H-benzo[d]imidaz...) Show SMILES FC(F)(F)c1ccccc1-c1ccc2nc([nH]c2c1)C1=NC2(CO1)CCCCC2 |t:22| Show InChI InChI=1S/C22H20F3N3O/c23-22(24,25)16-7-3-2-6-15(16)14-8-9-17-18(12-14)27-19(26-17)20-28-21(13-29-20)10-4-1-5-11-21/h2-3,6-9,12H,1,4-5,10-11,13H2,(H,26,27)	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research and Development Curated by ChEMBL					Assay Description Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assay				J Med Chem 54: 233-47 (2011) Article DOI: 10.1021/jm101075v BindingDB Entry DOI: 10.7270/Q20C4WRJ
					More data for this Ligand-Target Pair