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SMILES: Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1C[C@@H]2CCC(N)[C@H]2C1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 503374   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM503374 (2-((3aR,6aR)-4-Amino-hexahydro- cyclopenta-[c]pyrr...) Show SMILES Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1C[C@@H]2CCC(N)[C@H]2C1 |r,wU:25.28,wD:20.22,(-2.25,3.29,;-1.48,1.95,;.06,1.95,;.83,.62,;.06,-.71,;-1.48,-.71,;-2.25,-2.05,;-1.16,-3.14,;-3.79,-2.05,;-2.25,.62,;-3.79,.62,;-4.56,-.71,;-6.1,-.71,;-6.87,.62,;-6.1,1.95,;-6.87,3.29,;-4.56,1.95,;-3.79,3.29,;2.37,.62,;3.61,1.53,;4.86,.62,;6.4,.62,;6.87,-.84,;5.63,-1.75,;5.63,-3.29,;4.38,-.84,;2.84,-.84,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2JS9VKW
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM503374 (2-((3aR,6aR)-4-Amino-hexahydro- cyclopenta-[c]pyrr...) Show SMILES Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1C[C@@H]2CCC(N)[C@H]2C1 |r,wU:25.28,wD:20.22,(-2.25,3.29,;-1.48,1.95,;.06,1.95,;.83,.62,;.06,-.71,;-1.48,-.71,;-2.25,-2.05,;-1.16,-3.14,;-3.79,-2.05,;-2.25,.62,;-3.79,.62,;-4.56,-.71,;-6.1,-.71,;-6.87,.62,;-6.1,1.95,;-6.87,3.29,;-4.56,1.95,;-3.79,3.29,;2.37,.62,;3.61,1.53,;4.86,.62,;6.4,.62,;6.87,-.84,;5.63,-1.75,;5.63,-3.29,;4.38,-.84,;2.84,-.84,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...				Citation and Details BindingDB Entry DOI: 10.7270/Q2930X9N
					More data for this Ligand-Target Pair