BDBM50338244 6-(4-fluorobenzyl)-2-ureido-5,6-dihydro-4H-thieno[2,3-e]indazole-3-carboxamide::CHEMBL1681967

SMILES: NC(=O)Nc1sc-2c(CCc3c-2cnn3Cc2ccc(F)cc2)c1C(N)=O

InChI Key: InChIKey=GGYBQVWAOCXCDJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50338244   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human))	BDBM50338244 (6-(4-fluorobenzyl)-2-ureido-5,6-dihydro-4H-thieno[...) Show SMILES NC(=O)Nc1sc-2c(CCc3c-2cnn3Cc2ccc(F)cc2)c1C(N)=O Show InChI InChI=1S/C18H16FN5O2S/c19-10-3-1-9(2-4-10)8-24-13-6-5-11-14(16(20)25)17(23-18(21)26)27-15(11)12(13)7-22-24/h1-4,7H,5-6,8H2,(H2,20,25)(H3,21,23,26)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Kyorin Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human IKK-beta by substrate phosphorylation assay				Bioorg Med Chem Lett 21: 1758-62 (2011) Article DOI: 10.1016/j.bmcl.2011.01.069 BindingDB Entry DOI: 10.7270/Q2TX3FPV
					More data for this Ligand-Target Pair