BDBM50339583 4-[2'-(Naphthalen-1-yloxymethyl)-biphenyl-4-yl]-1-(2-o-tolyl-ethyl)-1H-[1,2,3]triazole::CHEMBL1688774

SMILES: Cc1ccccc1CCn1cc(nn1)-c1ccc(cc1)-c1ccccc1COc1cccc2ccccc12

InChI Key: InChIKey=PCQQGYOXKYHPCU-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50339583   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E synthase 2 (Homo sapiens (Human))	BDBM50339583 (4-[2'-(Naphthalen-1-yloxymethyl)-biphenyl-4-yl]-1-...) Show SMILES Cc1ccccc1CCn1cc(nn1)-c1ccc(cc1)-c1ccccc1COc1cccc2ccccc12 Show InChI InChI=1S/C34H29N3O/c1-25-9-2-3-10-26(25)21-22-37-23-33(35-36-37)29-19-17-28(18-20-29)31-14-6-5-12-30(31)24-38-34-16-8-13-27-11-4-7-15-32(27)34/h2-20,23H,21-22,24H2,1H3	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Salerno Curated by ChEMBL					Assay Description Inhibition of Prostaglandin E2 synthase-1 in IL-1beta stimulated microsomal fraction of human A549 cell assessed as PGE2 level by RP-HPLC				J Med Chem 54: 1565-75 (2011) Article DOI: 10.1021/jm101238d BindingDB Entry DOI: 10.7270/Q2SN098M
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50339583 (4-[2'-(Naphthalen-1-yloxymethyl)-biphenyl-4-yl]-1-...) Show SMILES Cc1ccccc1CCn1cc(nn1)-c1ccc(cc1)-c1ccccc1COc1cccc2ccccc12 Show InChI InChI=1S/C34H29N3O/c1-25-9-2-3-10-26(25)21-22-37-23-33(35-36-37)29-19-17-28(18-20-29)31-14-6-5-12-30(31)24-38-34-16-8-13-27-11-4-7-15-32(27)34/h2-20,23H,21-22,24H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Salerno Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human neutrophils				J Med Chem 54: 1565-75 (2011) Article DOI: 10.1021/jm101238d BindingDB Entry DOI: 10.7270/Q2SN098M
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50339583 (4-[2'-(Naphthalen-1-yloxymethyl)-biphenyl-4-yl]-1-...) Show SMILES Cc1ccccc1CCn1cc(nn1)-c1ccc(cc1)-c1ccccc1COc1cccc2ccccc12 Show InChI InChI=1S/C34H29N3O/c1-25-9-2-3-10-26(25)21-22-37-23-33(35-36-37)29-19-17-28(18-20-29)31-14-6-5-12-30(31)24-38-34-16-8-13-27-11-4-7-15-32(27)34/h2-20,23H,21-22,24H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Salerno Curated by ChEMBL					Assay Description Inhibition of human recombinant 5-lipooxygenase expressed in Escherichia coli MV1190 by cell free assay				J Med Chem 54: 1565-75 (2011) Article DOI: 10.1021/jm101238d BindingDB Entry DOI: 10.7270/Q2SN098M
					More data for this Ligand-Target Pair