BDBM50340265 7-(2-(3-(4-chloro-2-methoxy-5-methylphenyl)ureido)ethyl)-N-methylisoquinoline-3-carboxamide::CHEMBL1760007

SMILES: CNC(=O)c1cc2ccc(CCNC(=O)Nc3cc(C)c(Cl)cc3OC)cc2cn1

InChI Key: InChIKey=SDKUWIOISORZSZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50340265   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50340265 (7-(2-(3-(4-chloro-2-methoxy-5-methylphenyl)ureido)...) Show SMILES CNC(=O)c1cc2ccc(CCNC(=O)Nc3cc(C)c(Cl)cc3OC)cc2cn1 Show InChI InChI=1S/C22H23ClN4O3/c1-13-8-18(20(30-3)11-17(13)23)27-22(29)25-7-6-14-4-5-15-10-19(21(28)24-2)26-12-16(15)9-14/h4-5,8-12H,6-7H2,1-3H3,(H,24,28)(H2,25,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Merck Serono Curated by ChEMBL					Assay Description Inhibition of human cRAF using [gamma-33P-ATP] as a substrate by scintillation counting				Bioorg Med Chem Lett 21: 2264-9 (2011) Article DOI: 10.1016/j.bmcl.2011.02.108 BindingDB Entry DOI: 10.7270/Q2MS3T23
					More data for this Ligand-Target Pair