BDBM50340272 CHEMBL1760632::methyl 6-(2-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)ethyl)-1H-benzo[d]imidazol-2-ylcarbamate

SMILES: COC(=O)Nc1nc2ccc(CCNC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2[nH]1

InChI Key: InChIKey=NWHCBJSFIXGQTE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50340272   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50340272 (CHEMBL1760632 | methyl 6-(2-(3-(4-chloro-3-(triflu...) Show SMILES COC(=O)Nc1nc2ccc(CCNC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2[nH]1 Show InChI InChI=1S/C19H17ClF3N5O3/c1-31-18(30)28-16-26-14-5-2-10(8-15(14)27-16)6-7-24-17(29)25-11-3-4-13(20)12(9-11)19(21,22)23/h2-5,8-9H,6-7H2,1H3,(H2,24,25,29)(H2,26,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
Merck Serono Curated by ChEMBL					Assay Description Inhibition of human cRAF using [gamma-33P-ATP] as a substrate by scintillation counting				Bioorg Med Chem Lett 21: 2264-9 (2011) Article DOI: 10.1016/j.bmcl.2011.02.108 BindingDB Entry DOI: 10.7270/Q2MS3T23
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