BDBM50340621 ((cis)-4-(8-(6-methylpyridin-3-yl)quinazolin-2-ylamino)cyclohexyl)(pyrrolidin-1-yl)methanone::CHEMBL1761576

SMILES: Cc1ccc(cn1)-c1cccc2cnc(N[C@H]3CC[C@H](CC3)C(=O)N3CCCC3)nc12

InChI Key: InChIKey=YYDXTCLVCUQGMO-RVWIWJKTSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50340621   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transcription factor AP-1 (Homo sapiens (Human))	BDBM50340621 (((cis)-4-(8-(6-methylpyridin-3-yl)quinazolin-2-yla...) Show SMILES Cc1ccc(cn1)-c1cccc2cnc(N[C@H]3CC[C@H](CC3)C(=O)N3CCCC3)nc12 |r,wU:16.16,19.23,(12,-17.01,;10.66,-17.78,;10.65,-19.32,;9.32,-20.08,;7.99,-19.31,;7.99,-17.77,;9.33,-17,;6.66,-20.07,;5.32,-19.29,;3.99,-20.07,;3.99,-21.62,;5.32,-22.38,;5.3,-23.92,;6.64,-24.71,;7.98,-23.94,;9.31,-24.72,;10.65,-23.97,;10.65,-22.42,;12,-21.67,;13.33,-22.46,;13.31,-24,;11.97,-24.75,;14.67,-21.7,;14.69,-20.16,;16,-22.49,;15.98,-24.02,;17.44,-24.52,;18.36,-23.28,;17.47,-22.03,;8,-22.39,;6.66,-21.62,)| Show InChI InChI=1S/C25H29N5O/c1-17-7-8-19(15-26-17)22-6-4-5-20-16-27-25(29-23(20)22)28-21-11-9-18(10-12-21)24(31)30-13-2-3-14-30/h4-8,15-16,18,21H,2-3,9-14H2,1H3,(H,27,28,29)/t18-,21+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of c-Jun				Bioorg Med Chem Lett 21: 1719-23 (2011) Article DOI: 10.1016/j.bmcl.2011.01.079 BindingDB Entry DOI: 10.7270/Q2F1901V
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM50340621 (((cis)-4-(8-(6-methylpyridin-3-yl)quinazolin-2-yla...) Show SMILES Cc1ccc(cn1)-c1cccc2cnc(N[C@H]3CC[C@H](CC3)C(=O)N3CCCC3)nc12 |r,wU:16.16,19.23,(12,-17.01,;10.66,-17.78,;10.65,-19.32,;9.32,-20.08,;7.99,-19.31,;7.99,-17.77,;9.33,-17,;6.66,-20.07,;5.32,-19.29,;3.99,-20.07,;3.99,-21.62,;5.32,-22.38,;5.3,-23.92,;6.64,-24.71,;7.98,-23.94,;9.31,-24.72,;10.65,-23.97,;10.65,-22.42,;12,-21.67,;13.33,-22.46,;13.31,-24,;11.97,-24.75,;14.67,-21.7,;14.69,-20.16,;16,-22.49,;15.98,-24.02,;17.44,-24.52,;18.36,-23.28,;17.47,-22.03,;8,-22.39,;6.66,-21.62,)| Show InChI InChI=1S/C25H29N5O/c1-17-7-8-19(15-26-17)22-6-4-5-20-16-27-25(29-23(20)22)28-21-11-9-18(10-12-21)24(31)30-13-2-3-14-30/h4-8,15-16,18,21H,2-3,9-14H2,1H3,(H,27,28,29)/t18-,21+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of JNK3 by HRTF				Bioorg Med Chem Lett 21: 1719-23 (2011) Article DOI: 10.1016/j.bmcl.2011.01.079 BindingDB Entry DOI: 10.7270/Q2F1901V
					More data for this Ligand-Target Pair