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Enter Data

BDBM50341258 (Z)-5-(4-Methoxybenzylidene)-2-(p-tolyl)-5H-thiazol-4-one::CHEMBL1765888

SMILES: COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)cc1

InChI Key: InChIKey=MPJWONVAQZMDCG-WJDWOHSUSA-N

Data: 6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50341258
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50341258 ((Z)-5-(4-Methoxybenzylidene)-2-(p-tolyl)-5H-thiazo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Goethe-University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-LO in human PMNL S100 extract using arachidonic acid as substrate incubated for 15 mins prior to substrate addition measured after 10...				Eur J Med Chem 89: 503-23 (2014) Article DOI: 10.1016/j.ejmech.2014.10.054 BindingDB Entry DOI: 10.7270/Q2959K5T
Goethe-University Frankfurt Curated by ChEMBL					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50341258 ((Z)-5-(4-Methoxybenzylidene)-2-(p-tolyl)-5H-thiazo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
Goethe-University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-LO in human PMNL using arachidonic acid as substrate assessed as product formation incubated for 15 mins prior to substrate addition ...				Eur J Med Chem 89: 503-23 (2014) Article DOI: 10.1016/j.ejmech.2014.10.054 BindingDB Entry DOI: 10.7270/Q2959K5T
Goethe-University Frankfurt Curated by ChEMBL					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50341258 ((Z)-5-(4-Methoxybenzylidene)-2-(p-tolyl)-5H-thiazo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
Goethe University Frankfurt Curated by ChEMBL					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50341258 ((Z)-5-(4-Methoxybenzylidene)-2-(p-tolyl)-5H-thiazo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
Goethe University Frankfurt Curated by ChEMBL					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50341258 ((Z)-5-(4-Methoxybenzylidene)-2-(p-tolyl)-5H-thiazo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
Goethe University Frankfurt Curated by ChEMBL					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50341258 ((Z)-5-(4-Methoxybenzylidene)-2-(p-tolyl)-5H-thiazo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
Goethe University Frankfurt Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...				J Med Chem 54: 1943-7 (2011) Checked by Author Article DOI: 10.1021/jm101165z BindingDB Entry DOI: 10.7270/Q23T9J70
Goethe University Frankfurt Curated by ChEMBL					More data for this Ligand-Target Pair