BDBM50342279 (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-benzofuran-3-yl)methanone::CHEMBL1767079::US9725430, Compound 1g::US9962362, Compound 1g

SMILES: CCc1oc2cc(O)ccc2c1C(=O)c1cc(Br)c(O)c(Br)c1

InChI Key: InChIKey=FEXBXMFVRKZOOZ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50342279   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM50342279 ((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-be...) Show SMILES CCc1oc2cc(O)ccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 Show InChI InChI=1S/C17H12Br2O4/c1-2-13-15(10-4-3-9(20)7-14(10)23-13)16(21)8-5-11(18)17(22)12(19)6-8/h3-7,20,22H,2H2,1H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	138	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Anschutz Medical Campus Curated by ChEMBL					Assay Description Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...				J Med Chem 54: 2701-13 (2011) Article DOI: 10.1021/jm1015022 BindingDB Entry DOI: 10.7270/Q2P26ZDR
					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human))	BDBM50342279 ((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-be...) Show SMILES CCc1oc2cc(O)ccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 Show InChI InChI=1S/C17H12Br2O4/c1-2-13-15(10-4-3-9(20)7-14(10)23-13)16(21)8-5-11(18)17(22)12(19)6-8/h3-7,20,22H,2H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	2.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...				Bioorg Med Chem Lett 16: 5488-92 (2006) BindingDB Entry DOI: 10.7270/Q2ZK5JZ7
					More data for this Ligand-Target Pair
Eyes absent homolog 3 (EYA3) (Homo sapiens (Human))	BDBM50342279 ((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-be...) Show SMILES CCc1oc2cc(O)ccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 Show InChI InChI=1S/C17H12Br2O4/c1-2-13-15(10-4-3-9(20)7-14(10)23-13)16(21)8-5-11(18)17(22)12(19)6-8/h3-7,20,22H,2H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	2.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHILDREN HOSPITAL MEDICAL CENTER US Patent					Assay Description An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....				US Patent US9725430 (2017) BindingDB Entry DOI: 10.7270/Q23F4RSZ
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM50342279 ((3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxy-be...) Show SMILES CCc1oc2cc(O)ccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 Show InChI InChI=1S/C17H12Br2O4/c1-2-13-15(10-4-3-9(20)7-14(10)23-13)16(21)8-5-11(18)17(22)12(19)6-8/h3-7,20,22H,2H2,1H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
University of Colorado Anschutz Medical Campus Curated by ChEMBL					Assay Description Inhibition of human URAT1 expressed in human MDCK cells				J Med Chem 54: 2701-13 (2011) Article DOI: 10.1021/jm1015022 BindingDB Entry DOI: 10.7270/Q2P26ZDR
					More data for this Ligand-Target Pair