BDBM50343110 CHEMBL1771245::N-(3-(1,1-difluoroethyl)phenyl)-2-(pyridin-3-yl)-4-o-tolyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide

SMILES: Cc1ccccc1-c1nc(nc2CCN(Cc12)C(=O)Nc1cccc(c1)C(C)(F)F)-c1cccnc1

InChI Key: InChIKey=QCMKJUXGMZJXGD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50343110   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2Y purinoceptor 14 (Mus musculus)	BDBM50343110 (CHEMBL1771245 | N-(3-(1,1-difluoroethyl)phenyl)-2-...) Show SMILES Cc1ccccc1-c1nc(nc2CCN(Cc12)C(=O)Nc1cccc(c1)C(C)(F)F)-c1cccnc1 Show InChI InChI=1S/C28H25F2N5O/c1-18-7-3-4-11-22(18)25-23-17-35(27(36)32-21-10-5-9-20(15-21)28(2,29)30)14-12-24(23)33-26(34-25)19-8-6-13-31-16-19/h3-11,13,15-16H,12,14,17H2,1-2H3,(H,32,36)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Center for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...				Bioorg Med Chem Lett 21: 2832-5 (2011) Article DOI: 10.1016/j.bmcl.2011.03.084 BindingDB Entry DOI: 10.7270/Q20865N7
					More data for this Ligand-Target Pair