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SMILES: CNC(=O)c1cccc(c1)C1CCN(Cc2nc3ccccc3n2C)CC1

InChI Key: InChIKey=GAPMBGSOAFXGAH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50343304   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50343304
PNG
(CHEMBL1774106 | N-Methyl-3-(1-((1-methyl-1H-benzo[...)
Show SMILES CNC(=O)c1cccc(c1)C1CCN(Cc2nc3ccccc3n2C)CC1
Show InChI InChI=1S/C22H26N4O/c1-23-22(27)18-7-5-6-17(14-18)16-10-12-26(13-11-16)15-21-24-19-8-3-4-9-20(19)25(21)2/h3-9,14,16H,10-13,15H2,1-2H3,(H,23,27)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...

J Med Chem 54: 1724-39 (2011)


Article DOI: 10.1021/jm101414h
BindingDB Entry DOI: 10.7270/Q2222V3C
More data for this
Ligand-Target Pair