BDBM50343351 4,4,4-Trifluoro-1-[(R)-3-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)-pyrrolidin-1-yl]-butan-1-one::CHEMBL1773975
SMILES: FC(F)(F)CCC(=O)N1CC[C@H](C1)c1nc(no1)-c1cccs1
InChI Key: InChIKey=RQBFWGXMSPJGPK-SECBINFHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transcriptional repressor EthR (EthR) (Mycobacterium tuberculosis) | BDBM50343351 (4,4,4-Trifluoro-1-[(R)-3-(3-thiophen-2-yl-1,2,4-ox...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Lille Nord de France Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis EthR interaction to ethA promoter after 5 mins by surface plasmon resonance assay | J Med Chem 54: 2994-3010 (2011) Article DOI: 10.1021/jm200076a BindingDB Entry DOI: 10.7270/Q2SJ1KXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcriptional repressor EthR (EthR) (Mycobacterium tuberculosis) | BDBM50343351 (4,4,4-Trifluoro-1-[(R)-3-(3-thiophen-2-yl-1,2,4-ox...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Lille Nord de France Curated by ChEMBL | Assay Description Inhibition of EthR binding to ethA promoter in 106-bp biotinylated DNA preincubated for 5 mins measured for 3 mins by surface plasmon resonance assay | J Med Chem 55: 68-83 (2012) Article DOI: 10.1021/jm200825u BindingDB Entry DOI: 10.7270/Q2RX9CJW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcriptional repressor EthR (EthR) (Mycobacterium tuberculosis) | BDBM50343351 (4,4,4-Trifluoro-1-[(R)-3-(3-thiophen-2-yl-1,2,4-ox...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 400 | n/a | n/a | n/a | n/a |
Universit£ Lille Nord de France Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis H37Rv EthR in Mycobacterium tuberculosis H37Rv expressing GFP infected mouse in RAW264.7 cells assessed as p... | J Med Chem 55: 68-83 (2012) Article DOI: 10.1021/jm200825u BindingDB Entry DOI: 10.7270/Q2RX9CJW | |||||||||||
More data for this Ligand-Target Pair |