BDBM50343498 CHEMBL1773425::N-(4-(4-(4-Fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)pyridin-2-yl)acetamide

SMILES: CSc1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(NC(C)=O)c1

InChI Key: InChIKey=HLSURCXVAOWAFT-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343498   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50343498 (CHEMBL1773425 | N-(4-(4-(4-Fluorophenyl)-2-(methyl...) Show SMILES CSc1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(NC(C)=O)c1 Show InChI InChI=1S/C17H15FN4OS/c1-10(23)20-14-9-12(7-8-19-14)16-15(21-17(22-16)24-2)11-3-5-13(18)6-4-11/h3-9H,1-2H3,(H,21,22)(H,19,20,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University Tu£bingen Curated by ChEMBL					Assay Description Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assay				J Med Chem 54: 3283-97 (2011) Article DOI: 10.1021/jm101623p BindingDB Entry DOI: 10.7270/Q2W959H4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50343498 (CHEMBL1773425 | N-(4-(4-(4-Fluorophenyl)-2-(methyl...) Show SMILES CSc1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(NC(C)=O)c1 Show InChI InChI=1S/C17H15FN4OS/c1-10(23)20-14-9-12(7-8-19-14)16-15(21-17(22-16)24-2)11-3-5-13(18)6-4-11/h3-9H,1-2H3,(H,21,22)(H,19,20,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard Karls Universit£t T£bingen Curated by ChEMBL					Assay Description Inhibition of p38alpha MAPK (unknown origin) using ATF-2 as substrate after 1 hr by ELISA				Eur J Med Chem 175: 309-329 (2019) Article DOI: 10.1016/j.ejmech.2019.04.035
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50343498 (CHEMBL1773425 | N-(4-(4-(4-Fluorophenyl)-2-(methyl...) Show SMILES CSc1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(NC(C)=O)c1 Show InChI InChI=1S/C17H15FN4OS/c1-10(23)20-14-9-12(7-8-19-14)16-15(21-17(22-16)24-2)11-3-5-13(18)6-4-11/h3-9H,1-2H3,(H,21,22)(H,19,20,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	152	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard Karls Universit£t T£bingen Curated by ChEMBL					Assay Description Competitive inhibition of human recombinant full length GSK3beta using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated with enzyme for 10 min...				Eur J Med Chem 175: 309-329 (2019) Article DOI: 10.1016/j.ejmech.2019.04.035
					More data for this Ligand-Target Pair