BDBM50344127 6-(2,4-difluorophenoxy)-N-(2-(methylsulfonyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-amine::CHEMBL1778186

SMILES: CS(=O)(=O)CCNc1[nH]nc2nc(Oc3ccc(F)cc3F)ncc12

InChI Key: InChIKey=GGGSWPHAACVPQT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50344127   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50344127 (6-(2,4-difluorophenoxy)-N-(2-(methylsulfonyl)ethyl...) Show SMILES CS(=O)(=O)CCNc1[nH]nc2nc(Oc3ccc(F)cc3F)ncc12 Show InChI InChI=1S/C14H13F2N5O3S/c1-25(22,23)5-4-17-12-9-7-18-14(19-13(9)21-20-12)24-11-3-2-8(15)6-10(11)16/h2-3,6-7H,4-5H2,1H3,(H2,17,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into myelin basic protein				Bioorg Med Chem Lett 21: 3452-6 (2011) Article DOI: 10.1016/j.bmcl.2011.03.098 BindingDB Entry DOI: 10.7270/Q26H4HR7
					More data for this Ligand-Target Pair