BDBM50344324 2-isopropyl-3-(6-methoxypyridazin-3-yl)pyrazolo[1,5-a]pyridine::CHEMBL1779442

SMILES: COc1ccc(nn1)-c1c(nn2ccccc12)C(C)C

InChI Key: InChIKey=PBZJWHBRPXTHCY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50344324   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50344324 (2-isopropyl-3-(6-methoxypyridazin-3-yl)pyrazolo[1,...) Show SMILES COc1ccc(nn1)-c1c(nn2ccccc12)C(C)C Show InChI InChI=1S/C15H16N4O/c1-10(2)15-14(11-7-8-13(20-3)17-16-11)12-6-4-5-9-19(12)18-15/h4-10H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Heriot-Watt University Curated by ChEMBL					Assay Description Inhibition of human PDE5A catalytic domain using cAMP/cGMP substrate				Bioorg Med Chem Lett 21: 3307-12 (2011) Article DOI: 10.1016/j.bmcl.2011.04.021 BindingDB Entry DOI: 10.7270/Q2X067C3
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (PDE3) (Homo sapiens (Human))	BDBM50344324 (2-isopropyl-3-(6-methoxypyridazin-3-yl)pyrazolo[1,...) Show SMILES COc1ccc(nn1)-c1c(nn2ccccc12)C(C)C Show InChI InChI=1S/C15H16N4O/c1-10(2)15-14(11-7-8-13(20-3)17-16-11)12-6-4-5-9-19(12)18-15/h4-10H,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Heriot-Watt University Curated by ChEMBL					Assay Description Inhibition of human PDE3A catalytic domain using cAMP/cGMP substrate				Bioorg Med Chem Lett 21: 3307-12 (2011) Article DOI: 10.1016/j.bmcl.2011.04.021 BindingDB Entry DOI: 10.7270/Q2X067C3
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50344324 (2-isopropyl-3-(6-methoxypyridazin-3-yl)pyrazolo[1,...) Show SMILES COc1ccc(nn1)-c1c(nn2ccccc12)C(C)C Show InChI InChI=1S/C15H16N4O/c1-10(2)15-14(11-7-8-13(20-3)17-16-11)12-6-4-5-9-19(12)18-15/h4-10H,1-3H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.15E+5	n/a	n/a	n/a	n/a	n/a	n/a
Heriot-Watt University Curated by ChEMBL					Assay Description Inhibition of human PDE4B catalytic domain using cAMP/cGMP substrate				Bioorg Med Chem Lett 21: 3307-12 (2011) Article DOI: 10.1016/j.bmcl.2011.04.021 BindingDB Entry DOI: 10.7270/Q2X067C3
					More data for this Ligand-Target Pair