BDBM50344328 6-(2-isopropyl-7-methoxypyrazolo[1,5-a]pyridin-4-yl)-4,5-dihydropyridazin-3(2H)-one::CHEMBL1779446

SMILES: COc1ccc(C2=NNC(=O)CC2)c2cc(nn12)C(C)C

InChI Key: InChIKey=CRHPWLQRMNZHDW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50344328   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 3 (PDE3) (Homo sapiens (Human))	BDBM50344328 (6-(2-isopropyl-7-methoxypyrazolo[1,5-a]pyridin-4-y...) Show SMILES COc1ccc(C2=NNC(=O)CC2)c2cc(nn12)C(C)C |t:6| Show InChI InChI=1S/C15H18N4O2/c1-9(2)12-8-13-10(11-5-6-14(20)17-16-11)4-7-15(21-3)19(13)18-12/h4,7-9H,5-6H2,1-3H3,(H,17,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.96E+4	n/a	n/a	n/a	n/a	n/a	n/a
Heriot-Watt University Curated by ChEMBL					Assay Description Inhibition of human PDE3A catalytic domain using cAMP/cGMP substrate				Bioorg Med Chem Lett 21: 3307-12 (2011) Article DOI: 10.1016/j.bmcl.2011.04.021 BindingDB Entry DOI: 10.7270/Q2X067C3
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50344328 (6-(2-isopropyl-7-methoxypyrazolo[1,5-a]pyridin-4-y...) Show SMILES COc1ccc(C2=NNC(=O)CC2)c2cc(nn12)C(C)C |t:6| Show InChI InChI=1S/C15H18N4O2/c1-9(2)12-8-13-10(11-5-6-14(20)17-16-11)4-7-15(21-3)19(13)18-12/h4,7-9H,5-6H2,1-3H3,(H,17,20)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.61E+3	n/a	n/a	n/a	n/a	n/a	n/a
Heriot-Watt University Curated by ChEMBL					Assay Description Inhibition of human PDE4B catalytic domain using cAMP/cGMP substrate				Bioorg Med Chem Lett 21: 3307-12 (2011) Article DOI: 10.1016/j.bmcl.2011.04.021 BindingDB Entry DOI: 10.7270/Q2X067C3
					More data for this Ligand-Target Pair