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SMILES: Cc1ccc(cc1)-n1cnc2c(sc3nccc(NC(C)(C)C#C)c23)c1=O

InChI Key: InChIKey=CFHPFTHTFUZXBT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50345969   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 1


(Homo sapiens (Human))		BDBM50345969
PNG
(9-(1,1-Dimethyl-prop-2-ynylamino)-3-p-tolyl-3H-pyr...)
Show SMILES Cc1ccc(cc1)-n1cnc2c(sc3nccc(NC(C)(C)C#C)c23)c1=O
Show InChI InChI=1S/C21H18N4OS/c1-5-21(3,4)24-15-10-11-22-19-16(15)17-18(27-19)20(26)25(12-23-17)14-8-6-13(2)7-9-14/h1,6-12H,2-4H3,(H,22,24)
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Article
PubMed
n/an/a 171n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human mGluR1

Bioorg Med Chem Lett 19: 3199-203 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.104
BindingDB Entry DOI: 10.7270/Q27081SJ
More data for this
Ligand-Target Pair