BDBM50349690 CHEMBL1809047

SMILES: COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCNC(=O)C1

InChI Key: InChIKey=MMJIWYMCQKGGQO-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50349690   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50349690 (CHEMBL1809047) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCNC(=O)C1 Show InChI InChI=1S/C22H20ClN7O2/c1-32-18-10-14(29-9-7-24-20(31)13-29)5-6-16(18)27-22-26-11-15(23)21(28-22)17-12-25-19-4-2-3-8-30(17)19/h2-6,8,10-12H,7,9,13H2,1H3,(H,24,31)(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of auto-phosphorylation of IGFR1 by cell based assay				Bioorg Med Chem Lett 21: 4702-4 (2011) Article DOI: 10.1016/j.bmcl.2011.06.090 BindingDB Entry DOI: 10.7270/Q2QZ2B9Q
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50349690 (CHEMBL1809047) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCNC(=O)C1 Show InChI InChI=1S/C22H20ClN7O2/c1-32-18-10-14(29-9-7-24-20(31)13-29)5-6-16(18)27-22-26-11-15(23)21(28-22)17-12-25-19-4-2-3-8-30(17)19/h2-6,8,10-12H,7,9,13H2,1H3,(H,24,31)(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of auto-phosphorylation of IGFR1				Bioorg Med Chem Lett 21: 4702-4 (2011) Article DOI: 10.1016/j.bmcl.2011.06.090 BindingDB Entry DOI: 10.7270/Q2QZ2B9Q
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50349690 (CHEMBL1809047) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCNC(=O)C1 Show InChI InChI=1S/C22H20ClN7O2/c1-32-18-10-14(29-9-7-24-20(31)13-29)5-6-16(18)27-22-26-11-15(23)21(28-22)17-12-25-19-4-2-3-8-30(17)19/h2-6,8,10-12H,7,9,13H2,1H3,(H,24,31)(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human ERG by electrophysiology assay				Bioorg Med Chem Lett 21: 4702-4 (2011) Article DOI: 10.1016/j.bmcl.2011.06.090 BindingDB Entry DOI: 10.7270/Q2QZ2B9Q
					More data for this Ligand-Target Pair