BDBM50349701 CHEMBL1809070

SMILES: COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(=O)[C@H](C)O

InChI Key: InChIKey=RYSJYSNSALLKRM-INIZCTEOSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50349701   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50349701 (CHEMBL1809070) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(=O)[C@H](C)O |r| Show InChI InChI=1S/C25H26ClN7O3/c1-16(34)24(35)32-11-9-31(10-12-32)17-6-7-19(21(13-17)36-2)29-25-28-14-18(26)23(30-25)20-15-27-22-5-3-4-8-33(20)22/h3-8,13-16,34H,9-12H2,1-2H3,(H,28,29,30)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of auto-phosphorylation of IGFR1				Bioorg Med Chem Lett 21: 4702-4 (2011) Article DOI: 10.1016/j.bmcl.2011.06.090 BindingDB Entry DOI: 10.7270/Q2QZ2B9Q
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50349701 (CHEMBL1809070) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(=O)[C@H](C)O |r| Show InChI InChI=1S/C25H26ClN7O3/c1-16(34)24(35)32-11-9-31(10-12-32)17-6-7-19(21(13-17)36-2)29-25-28-14-18(26)23(30-25)20-15-27-22-5-3-4-8-33(20)22/h3-8,13-16,34H,9-12H2,1-2H3,(H,28,29,30)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human ERG by electrophysiology assay				Bioorg Med Chem Lett 21: 4702-4 (2011) Article DOI: 10.1016/j.bmcl.2011.06.090 BindingDB Entry DOI: 10.7270/Q2QZ2B9Q
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50349701 (CHEMBL1809070) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(=O)[C@H](C)O |r| Show InChI InChI=1S/C25H26ClN7O3/c1-16(34)24(35)32-11-9-31(10-12-32)17-6-7-19(21(13-17)36-2)29-25-28-14-18(26)23(30-25)20-15-27-22-5-3-4-8-33(20)22/h3-8,13-16,34H,9-12H2,1-2H3,(H,28,29,30)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of auto-phosphorylation of IGFR1 by cell based assay				Bioorg Med Chem Lett 21: 4702-4 (2011) Article DOI: 10.1016/j.bmcl.2011.06.090 BindingDB Entry DOI: 10.7270/Q2QZ2B9Q
					More data for this Ligand-Target Pair