BDBM50349703 CHEMBL1809072

SMILES: COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(=O)CN

InChI Key: InChIKey=YCVCMJDYPSNZTE-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50349703   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50349703 (CHEMBL1809072) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(=O)CN Show InChI InChI=1S/C24H25ClN8O2/c1-35-20-12-16(31-8-10-32(11-9-31)22(34)13-26)5-6-18(20)29-24-28-14-17(25)23(30-24)19-15-27-21-4-2-3-7-33(19)21/h2-7,12,14-15H,8-11,13,26H2,1H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of auto-phosphorylation of IGFR1				Bioorg Med Chem Lett 21: 4702-4 (2011) Article DOI: 10.1016/j.bmcl.2011.06.090 BindingDB Entry DOI: 10.7270/Q2QZ2B9Q
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50349703 (CHEMBL1809072) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(=O)CN Show InChI InChI=1S/C24H25ClN8O2/c1-35-20-12-16(31-8-10-32(11-9-31)22(34)13-26)5-6-18(20)29-24-28-14-17(25)23(30-24)19-15-27-21-4-2-3-7-33(19)21/h2-7,12,14-15H,8-11,13,26H2,1H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human ERG by electrophysiology assay				Bioorg Med Chem Lett 21: 4702-4 (2011) Article DOI: 10.1016/j.bmcl.2011.06.090 BindingDB Entry DOI: 10.7270/Q2QZ2B9Q
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50349703 (CHEMBL1809072) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCN(CC1)C(=O)CN Show InChI InChI=1S/C24H25ClN8O2/c1-35-20-12-16(31-8-10-32(11-9-31)22(34)13-26)5-6-18(20)29-24-28-14-17(25)23(30-24)19-15-27-21-4-2-3-7-33(19)21/h2-7,12,14-15H,8-11,13,26H2,1H3,(H,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of auto-phosphorylation of IGFR1 by cell based assay				Bioorg Med Chem Lett 21: 4702-4 (2011) Article DOI: 10.1016/j.bmcl.2011.06.090 BindingDB Entry DOI: 10.7270/Q2QZ2B9Q
					More data for this Ligand-Target Pair