BDBM50349708 CHEMBL1809077

SMILES: COc1ccc(cc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCNCC1

InChI Key: InChIKey=SULXDXZNCPQTOL-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50349708   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50349708 (CHEMBL1809077) Show SMILES COc1ccc(cc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCNCC1 Show InChI InChI=1S/C22H22ClN7O/c1-31-19-6-5-15(29-10-7-24-8-11-29)12-17(19)27-22-26-13-16(23)21(28-22)18-14-25-20-4-2-3-9-30(18)20/h2-6,9,12-14,24H,7-8,10-11H2,1H3,(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of auto-phosphorylation of IGFR1				Bioorg Med Chem Lett 21: 4702-4 (2011) Article DOI: 10.1016/j.bmcl.2011.06.090 BindingDB Entry DOI: 10.7270/Q2QZ2B9Q
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50349708 (CHEMBL1809077) Show SMILES COc1ccc(cc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCNCC1 Show InChI InChI=1S/C22H22ClN7O/c1-31-19-6-5-15(29-10-7-24-8-11-29)12-17(19)27-22-26-13-16(23)21(28-22)18-14-25-20-4-2-3-9-30(18)20/h2-6,9,12-14,24H,7-8,10-11H2,1H3,(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human ERG by electrophysiology assay				Bioorg Med Chem Lett 21: 4702-4 (2011) Article DOI: 10.1016/j.bmcl.2011.06.090 BindingDB Entry DOI: 10.7270/Q2QZ2B9Q
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50349708 (CHEMBL1809077) Show SMILES COc1ccc(cc1Nc1ncc(Cl)c(n1)-c1cnc2ccccn12)N1CCNCC1 Show InChI InChI=1S/C22H22ClN7O/c1-31-19-6-5-15(29-10-7-24-8-11-29)12-17(19)27-22-26-13-16(23)21(28-22)18-14-25-20-4-2-3-9-30(18)20/h2-6,9,12-14,24H,7-8,10-11H2,1H3,(H,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of auto-phosphorylation of IGFR1 by cell based assay				Bioorg Med Chem Lett 21: 4702-4 (2011) Article DOI: 10.1016/j.bmcl.2011.06.090 BindingDB Entry DOI: 10.7270/Q2QZ2B9Q
					More data for this Ligand-Target Pair